- Winona is a city located in Winona County, Minnesota, United States. It is located in the southeastern part of the state along the Mississippi River. The city is known for its natural beauty, with steep bluffs and scenic views of the river. Winona is home to several colleges and universities, including Winona State University and Saint Mary's University of Minnesota. The city has a rich history, with many historic buildings and landmarks, such as the Winona County Courthouse and the Polish Cultural Institute and Museum. Winona also offers a variety of recreational activities, including boating, fishing, hiking, and biking. The city has a vibrant arts and cultural scene, with numerous galleries, theaters, and music venues. Overall, Winona is a charming and picturesque city that offers a blend of natural beauty, history, and cultural attractions.