Walterboro is a city located in Colleton County, South Carolina, United States. It is the county seat and has a population of approximately 5,271 people as of the 2020 census. The city is known for its historic downtown area, which features many well-preserved antebellum homes and buildings. Walterboro is also home to a number of museums, including the Colleton County Museum and Farmers Market, which showcases the area's history and agricultural heritage. The city hosts various events throughout the year, such as the annual Rice Festival, which celebrates the region's rice-growing history. The city's location along Interstate 95 makes it easily accessible for travelers passing through the area.