- Tupelo is a city located in Lee County, Mississippi. It is the seventh-largest city in the state and serves as the county seat. Tupelo is known for its rich music history, being the birthplace of legendary musician Elvis Presley. The city has several attractions related to Elvis, including the Elvis Presley Birthplace and Museum. Tupelo is also home to the Tupelo Automobile Museum, which showcases over 100 antique and classic cars. The city has a vibrant downtown area with shops, restaurants, and a thriving arts scene. Additionally, Tupelo is known for its strong economy, with industries such as manufacturing, healthcare, and education playing a major role.