Toksook Bay is a city located in the Yukon-Kuskokwim Delta region of southwest Alaska, United States. It is part of the Bethel Census Area and has a population of approximately 590 people. The city is primarily inhabited by Alaska Native Yup'ik Eskimos, who rely on subsistence hunting, fishing, and gathering for their livelihoods. Toksook Bay is known for its rich cultural heritage and traditional practices, including dance festivals and events that showcase Yup'ik traditions. The city is accessible by air and sea, and its economy is primarily based on subsistence activities and local services.