- Sanford is a city located in Seminole County, Florida, United States. It is part of the Orlando-Kissimmee-Sanford metropolitan area. Sanford is situated on the southern shore of Lake Monroe and is known for its historic downtown, beautiful waterfront, and rich cultural heritage. The city has a diverse community and offers a variety of recreational activities, including boating, fishing, and hiking. Popular attractions in Sanford include the Central Florida Zoo & Botanical Gardens, the Wayne Densch Performing Arts Center, and the Historic Sanford Memorial Stadium. Sanford also hosts various events and festivals throughout the year, such as the St. Johns River Festival of the Arts and the Alive After 5 street party.