- Saginaw is a city in the U.S. state of Michigan and is located in Saginaw County. It is situated along the Saginaw River and is about 90 miles north of Detroit. With a population of around 48,000 people, Saginaw is the largest municipality in the Great Lakes Bay Region. The city has a rich history in manufacturing, particularly in the automotive and lumber industries. Today, Saginaw is known for its diverse economy, with sectors such as healthcare, education, and retail contributing to its growth. The city offers various recreational opportunities, including parks, museums, and cultural events, making it an attractive place to live or visit.