The city of Poplar Bluff is located in Butler County, in the southeastern part of the state of Missouri, United States. It is approximately 150 miles south of St. Louis and 120 miles north of Memphis, Tennessee. Poplar Bluff is the county seat of Butler County and has a population of around 17,000 people. The city is known for its historical downtown area, cultural events, outdoor recreational opportunities, and being a regional healthcare and economic center.