Pilot Station is a city located on the Yukon River in the Kusilvak Census Area in the U.S. state of Alaska. It is primarily a Yup'ik community and is a hub for fishing and hunting activities. The city has a population of around 550 people according to the 2010 census. The economy of Pilot Station is largely fueled by subsistence activities, with hunting, fishing, and gathering being the primary sources of food and income for the residents. The city is also home to a school, health clinic, and other basic amenities.