- Paducah is a city located in McCracken County, Kentucky, United States. The city has a population of approximately 24,850 as of 2020 and covers an area of 20.6 square miles. Paducah is situated at the confluence of the Ohio and Tennessee rivers and serves as the county seat of McCracken County. The city has a rich history, with its roots dating back to the early 19th century. Today, Paducah is known for its vibrant arts community, historic downtown district, and being home to the National Quilt Museum. The city also serves as a regional hub for healthcare, education, and commerce.