- Nogales is a city located on the border between the United States and Mexico. It simultaneously borders the city of Nogales, Sonora in Mexico and Nogales, Arizona in the United States. The name "Nogales" means "walnut trees" in Spanish. It is the largest Arizona border city and is part of Santa Cruz County. Nogales serves as a major port of entry for goods and people traveling between the two countries. The city has a rich cultural heritage and is known for its vibrant Mexican-American community. Nogales offers various attractions and activities, including historical sites, shopping centers, restaurants, and outdoor recreational areas.