- Nenana is a city in the Interior of Alaska, United States. It is located along the Nenana River, approximately 55 miles southwest of Fairbanks. The city is known for its location on the Alaska Railroad and its annual ice classic event, where participants guess the exact date and time when the ice will break up on the river in the spring. Nenana has a small population, and the economy is mainly supported by tourism, transportation, and subsistence activities.