- Natchez is a city in the southwestern part of the state of Mississippi, in the United States. It is the county seat of Adams County and has a population of approximately 15,000 people. Natchez is known for its rich history, particularly its antebellum architecture and heritage. It was a significant port on the Mississippi River during the 19th century and was a major center for the cotton trade. Today, Natchez is a popular tourist destination, attracting visitors with its historic sites, beautiful scenery, and cultural events. Some notable attractions in the city include the historic Natchez Trace Parkway, the Natchez National Historical Park, and the Natchez City Cemetery.