- Milan is a city located in the Lombardy region of northern Italy. It is the capital of the province of Milan and is the second most populous city in Italy after Rome. Milan is known as a global fashion and design capital, and is home to many high-end fashion brands and luxury shopping districts such as the Quadrilatero della Moda. The city is also renowned for its stunning architecture, with landmarks such as the Milan Cathedral, Sforza Castle, and the famous La Scala opera house. Milan is a major economic and financial hub, and is home to the Italian Stock Exchange. The city is also known for its vibrant nightlife, cultural scene, and historical sites, making it a popular tourist destination.