- Medford is a city located in Middlesex County, Massachusetts, United States. It is located approximately 3.2 miles northwest of downtown Boston. Medford has a population of around 57,000 people and covers an area of about 8.6 square miles. The city is known for its rich history, including the founding of Tufts University in 1852. Medford is also home to several parks and recreational areas, as well as numerous cultural and arts institutions. The city offers a suburban feel with a mix of residential, commercial, and industrial areas.