- Kayes city is the capital of the Kayes Region in western Mali, Africa. It is located on the edge of the Senegal River and is the largest city in the region. Kayes is known for its hot and dry climate, and it serves as an important transportation hub and commercial center for the surrounding area. The city has a population of around 127,000 people, with a mix of ethnic groups including the Bambara, Soninke, and Fulani. Kayes is also a popular tourist destination, known for its historical sites, markets, and nearby natural attractions such as the Faleme Falls.