Kasigluk is a city located in the Bethel Census Area in southwestern Alaska, United States. It is a small, remote community with a population of around 600 people as of the 2020 census. Kasigluk is predominantly inhabited by Yup'ik Eskimo people and is known for its rich Native Alaskan culture and traditions. The city is located on the Johnson River and is accessible mainly by small airplanes or boats. The primary industries in Kasigluk are subsistence hunting, fishing, and limited tourism.