- Kansas City is the largest city in the state of Missouri, located in the Midwest region of the United States. It is split into two separate municipalities, Kansas City, Missouri, and Kansas City, Kansas, with the majority of the city being in Missouri. The city is known for its rich history, jazz and blues music, barbecue cuisine, and sports teams such as the Kansas City Chiefs (football) and Kansas City Royals (baseball). It is also home to several cultural attractions, including the Nelson-Atkins Museum of Art and the National World War I Museum and Memorial.