- Joplin is a city in southwest Missouri, in the United States. It is the largest city in Jasper County and the 12th largest city in the state. Joplin is known for its vibrant arts community, outdoor recreational opportunities, and vibrant downtown area. The city was severely affected by the Joplin tornado in 2011, but has since rebuilt and revitalized many areas. Joplin is home to several colleges and universities, including Missouri Southern State University.