- Ithaca is a city located in Tompkins County, New York, United States. It is situated in the Finger Lakes region of the state and is known for its natural beauty, including several waterfalls, gorges, and Cayuga Lake. Ithaca is also home to Cornell University and Ithaca College, which contribute to its vibrant academic and cultural scene. The city is frequently listed as one of the best places to live in the United States, with a strong emphasis on sustainability, outdoor recreation, and community engagement.