- Hyannis is a village located in Barnstable, Massachusetts. It is situated in the town of Barnstable and is the largest of seven villages within the town. Hyannis is known for its beautiful coastline, vibrant downtown area, and for being the largest commercial center on Cape Cod. It is also a popular tourist destination, offering various attractions such as beaches, shopping centers, restaurants, and cultural sites. Hyannis is well-connected to other parts of Cape Cod and the mainland, thanks to its transportation infrastructure, including a ferry service to the islands of Martha's Vineyard and Nantucket, as well as a regional airport.