- Eunice is a city located in St. Landry Parish, Louisiana, United States. It is situated in the Acadiana region and has a population of approximately 10,227 residents as of the 2020 census. Eunice is known for its vibrant Cajun culture, with strong ties to music and food. The city hosts the Louisiana State Medical Museum and a variety of festivals, including the Cajun Music Festival and the World Championship Crawfish Etouffee Cookoff.