- Crewe is a town in Cheshire, England. It is located on the River Crewe between the cities of Manchester and Birmingham. Crewe is known for its railway heritage, as it has been a major railway junction since the 19th century. The town became an important hub for locomotive manufacturing and engineering, and is home to the Crewe Works, which was once the largest railway engineering facility in the world. Crewe also has a rich cultural history, with several historic buildings, museums, and art galleries. The town is home to a diverse population and offers a range of amenities, including shopping centers, restaurants, and sports facilities.