- Clemson is a city located in Pickens and Anderson counties in the state of South Carolina, United States. It is known for being the home of Clemson University, a prestigious public research university. The city has a population of approximately 17,000 residents, with a significant portion being students and faculty members of the university. Apart from being a college town, Clemson is also known for its vibrant community, scenic beauty, and outdoor recreational opportunities. The city offers a variety of amenities, including restaurants, shops, parks, and events, making it a popular destination for residents and visitors alike.