- Central City may refer to:
- 1. Central City, Kentucky: a city in Muhlenberg County in western Kentucky, United States.
- 2. Central City, Colorado: a historic mining town turned tourist destination in Gilpin County, Colorado, United States.
- 3. Central City, Iowa: a city in Linn County in eastern Iowa, United States.
- 4. Central City, Nebraska: a city in Merrick County in central Nebraska, United States.
- 5. Central City, New Orleans: a neighborhood in New Orleans, Louisiana, United States.
- 6. Central City, Pennsylvania: a borough in Somerset County in southwestern Pennsylvania, United States.
- 7. Central City, South Dakota: a town in Lawrence County in western South Dakota, United States.
- 8. Central City, Illinois: a village in Marion County in southern Illinois, United States.